SCHEMBL29669727

SCHEMBL29669727

FC(F)(F)c1cccc(-c2ccccc2P(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.46
ADORA1 P30542 2/20 0.46
RORC P51449 1/20 0.46
RORB Q92753 1/20 0.46
MAOB P27338 1/20 0.43
SCN2A Q99250 1/20 0.42
ALDH1A1 P00352 2/20 0.42
TSHR P16473 1/20 0.41
CNR2 P34972 1/20 0.40
AKR1C3 P42330 2/20 0.40
AKR1C2 P52895 2/20 0.40
KDM4E B2RXH2 2/20 0.40
HTR2C P28335 2/20 0.40
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PTPN5 P54829 1/20 0.40
KIF11 P52732 1/20 0.40
EPHX2 P34913 1/20 0.40
PTPN1 P18031 1/20 0.40
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21040615 0.83 KIF11 (0.52) MAOBSCN2AALDH1A1TSHRKDM4E
SCHEMBL29669657 0.82 KIF11 (0.46) ADORA2AADORA1ALDH1A1TSHRKIF11
SCHEMBL28294522 0.82 KIF11 (0.46) ADORA2AADORA1ALDH1A1TSHRKIF11
SCHEMBL28907992 0.82 KIF11 (0.46) ADORA2AADORA1ALDH1A1TSHRKIF11
SCHEMBL28667956 0.81 ADORA2A (0.54) ADORA2AADORA1RORCRORBMAOB
SCHEMBL17840165 0.80 RORC (0.57) ADORA2AADORA1RORCRORBMAOB
SCHEMBL4004840 0.78 TDP1 (0.50) ALDH1A1KDM4EHPGD
SCHEMBL29635182 0.78 TDP1 (0.50) ALDH1A1KDM4EHPGD
SCHEMBL7799500 0.77 TDP1 (0.48) ALDH1A1KDM4EHPGD
SCHEMBL32685426 0.77 TDP1 (0.48) ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114478627-B Allylated monophosphine ligand and preparation method thereof 湖北大学 2023-06-20 CN disclosed
CN-114478627-A Allylation monophosphine ligand and preparation method thereof 湖北大学 2022-05-13 CN disclosed