Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23672380 | 0.85 | NNMT (0.46) | PIK3CBNNMTPARP1SIRT3TDP1 | |
| SCHEMBL2027879 | 0.82 | KDM4E (0.63) | KDM4EASPHKDM8KCNQ3KCNQ2 | |
| SCHEMBL14864589 | 0.82 | KDM4E (0.44) | KDM4EASPHKDM8TDP1UHRF1 | |
| SCHEMBL31320114 | 0.82 | KDM4E (0.63) | KDM4EASPHKDM8KCNQ3KCNQ2 | |
| SCHEMBL17275841 | 0.81 | KDM4E (0.43) | KDM4EASPHKDM8UHRF1KCNQ3 | |
| SCHEMBL30637389 | 0.80 | P2RX7 (0.44) | KDM4EASPHKDM8TDP1HTT | |
| SCHEMBL11414590 | 0.80 | PARP1 (0.40) | KDM4EASPHKDM8NNMTPARP1 | |
| SCHEMBL31337711 | 0.80 | KDM4E (0.46) | KDM4EASPHKDM8NNMTPARP1 | |
| SCHEMBL24724391 | 0.80 | KDM4E (0.46) | KDM4EASPHKDM8NNMTPARP1 | |
| SCHEMBL24662962 | 0.78 | UHRF1 (0.52) | PIK3CBNNMTPARP1SIRT3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |