Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29670369 | 0.85 | P2RX3 (0.38) | KCNK3TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL24484014 | 0.84 | KCNK3 (0.38) | KCNK3TP53MEN1KMT2AMAPT | |
| SCHEMBL24483968 | 0.83 | NR1H2 (0.32) | KCNK3NR1H2NR1H3 | |
| SCHEMBL24469898 | 0.83 | P2RX7 (0.33) | KCNK3TP53NR1H2NR1H3 | |
| SCHEMBL24469803 | 0.82 | NR1H2 (0.32) | KCNK3NR1H2NR1H3 | |
| SCHEMBL24483821 | 0.82 | SCD (0.34) | TP53MEN1KMT2AMAPTLMNA | |
| SCHEMBL26841995 | 0.82 | NR1H2 (0.33) | NR1H2NR1H3 | |
| SCHEMBL24470059 | 0.81 | P2RX7 (0.32) | TP53MAPTALDH1A1TSHRNR1H2 | |
| SCHEMBL26841989 | 0.81 | NR1H2 (0.33) | KCNK3TP53NR1H2NR1H3 | |
| SCHEMBL26841980 | 0.81 | NR1H2 (0.33) | KCNK3NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |