⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24470109 | 0.91 | PLAT (0.31) | — | |
| SCHEMBL24469873 | 0.72 | PDE3B (0.37) | — | |
| SCHEMBL24469822 | 0.71 | PLAT (0.32) | — | |
| SCHEMBL24469760 | 0.70 | PLAT (0.34) | — | |
| SCHEMBL24469986 | 0.61 | PDE3B (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL29457296 | 0.58 | DRD3 (0.39) | — | |
| Trifluoroacetic Acid SCHEMBL34469351 | 0.58 | PNMT (0.40) | — | |
| Trifluoroacetic Acid SCHEMBL28435693 | 0.57 | KDM4E (0.32) | — | |
| Trifluoroacetic Acid SCHEMBL29192027 | 0.56 | KDM1A (0.39) | — | |
| Trifluoroacetic Acid SCHEMBL31569106 | 0.56 | PNMT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820773-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |
| US-20220169650-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-06-02 | — | — | US | disclosed |