Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28761395 | 0.90 | HDAC1 (0.61) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL241664 | 0.89 | GSK3B (0.70) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10789857 | 0.81 | TSHR (0.52) | SMN1; SMN2KMT2APOLBALDH1A1LMNA | |
| SCHEMBL7238392 | 0.81 | USP5 (0.44) | SMN1; SMN2KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL20799581 | 0.81 | GSK3B (0.59) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL11060497 | 0.81 | OGG1 (0.63) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL100952 | 0.81 | NR4A2 (0.65) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL133319 | 0.80 | HDAC1 (0.75) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL6286372 | 0.79 | GSK3B (0.57) | GSK3BHDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL6458755 | 0.79 | NPC1 (0.67) | SMN1; SMN2KMT2AMEN1HSD11B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |