Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Rebamipide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.78 |
| ▸ | ERAP2 | Q6P179 | 8/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 7/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.45 |
| ▸ | ITGAL | P20701 | 3/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rebamipide SCHEMBL16667091 | 1.00 | UBASH3B (0.78) | UBASH3BERAP2LNPEPERAP1PPARG | |
| Rebamipide SCHEMBL2866138 | 0.90 | UBASH3B (0.92) | UBASH3BERAP2PPARGF11ITGB2 | |
| SCHEMBL296717 | 0.89 | UBASH3B (0.66) | UBASH3BERAP2LNPEPERAP1PPARG | |
| Rebamipide SCHEMBL23346201 | 0.88 | UBASH3B (1.00) | UBASH3BERAP2PPARGF11ITGB2 | |
| Rebamipide SCHEMBL5794018 | 0.88 | UBASH3B (1.00) | UBASH3BERAP2PPARGF11ITGB2 | |
| Rebamipide SCHEMBL21623658 | 0.88 | UBASH3B (1.00) | UBASH3BERAP2PPARGF11ITGB2 | |
| Rebamipide SCHEMBL221527 | 0.88 | UBASH3B (1.00) | UBASH3BERAP2PPARGF11ITGB2 | |
| Rebamipide SCHEMBL29560992 | 0.88 | UBASH3B (1.00) | UBASH3BERAP2PPARGF11ITGB2 | |
| Rebamipide SCHEMBL297016 | 0.88 | UBASH3B (0.72) | UBASH3BERAP2LNPEPERAP1PPARG | |
| Rebamipide SCHEMBL9114879 | 0.87 | UBASH3B (0.98) | UBASH3BERAP2PPARGF11ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253619-B1 | Amine salt of carbostyril derivative | OTSUKA PHARMA CO LTD (JP) | 2012-03-14 | — | — | EP | disclosed |
| EP-2253619-A1 | Amine salt of carbostyril derivative | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |