Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.57 |
| ▸ | AKT1 | P31749 | 14/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755300 | 1.00 | PIK3CD (0.57) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL28755139 | 0.92 | PIK3CD (0.48) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL29671991 | 0.92 | PIK3CD (0.48) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL29671958 | 0.92 | MAPT (0.51) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL28755148 | 0.92 | MAPT (0.51) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL28755225 | 0.91 | AKT1 (0.51) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL29671949 | 0.91 | AKT1 (0.51) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL28755228 | 0.91 | MAPT (0.50) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL29672019 | 0.91 | MAPT (0.50) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 | |
| SCHEMBL28755175 | 0.91 | LMNA (0.51) | PIK3CDPIK3CBAKT1PIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | claimed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | claimed |
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | disclosed |