Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | AKT1 | P31749 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29671962 | 1.00 | LMNA (0.51) | LMNATSHRPIK3CDPIK3CBMAPT | |
| SCHEMBL29671970 | 0.92 | LMNA (0.52) | LMNATSHRMAPTMCHR1TRPA1 | |
| SCHEMBL28755231 | 0.92 | LMNA (0.52) | LMNATSHRMAPTMCHR1TRPA1 | |
| SCHEMBL29671886 | 0.91 | AKT1 (0.55) | LMNAPIK3CDPIK3CBMAPTAKT1 | |
| SCHEMBL28755083 | 0.91 | AKT1 (0.55) | LMNAPIK3CDPIK3CBMAPTAKT1 | |
| SCHEMBL28755300 | 0.91 | PIK3CD (0.57) | LMNAPIK3CDPIK3CBMAPTAKT1 | |
| SCHEMBL29671952 | 0.91 | PIK3CD (0.57) | LMNAPIK3CDPIK3CBMAPTAKT1 | |
| SCHEMBL28755139 | 0.90 | PIK3CD (0.48) | PIK3CDPIK3CBMAPTAKT1PIK3CA | |
| SCHEMBL29671991 | 0.90 | PIK3CD (0.48) | PIK3CDPIK3CBMAPTAKT1PIK3CA | |
| SCHEMBL28755225 | 0.89 | AKT1 (0.51) | LMNATSHRPIK3CDPIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | claimed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | claimed |
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | disclosed |