Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 20/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2963032 | 0.99 | MCHR1 (0.78) | MCHR1KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12339978 | 0.91 | MCHR1 (0.83) | MCHR1KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12340391 | 0.90 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL2955497 | 0.90 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12339973 | 0.89 | MCHR1 (0.83) | MCHR1KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12340341 | 0.89 | MCHR1 (0.83) | MCHR1KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12340338 | 0.89 | MCHR1 (0.83) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL539304 | 0.89 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL2958017 | 0.88 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12340388 | 0.88 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| EP-2121654-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | Albany Molecular Research, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008086404-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086404-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | CYP3A5, PDXK, PNPO | MCHR1 4525/4885KCNH2 917/4885CYP3A4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.