Sugi Predict

Sugi Predict / Compounds / SCHEMBL2967367

SCHEMBL2967367

SCHEMBL2967367

CCOC(=O)c1c(C(F)(F)C(F)(F)F)nn2c(OC)ccc(CO)c12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4D Q08499 3/20 0.38
▸ MAPT P10636 4/20 0.37
▸ POLB P06746 4/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ PLAT P00750 1/20 0.36
▸ HDAC4 P56524 2/20 0.35
▸ HDAC6 Q9UBN7 2/20 0.35
▸ ADORA3 P0DMS8 1/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ HPGD P15428 2/20 0.34
▸ TP53 P04637 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ DGAT1 O75907 1/20 0.33
▸ SOAT1 P35610 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ HDAC3 O15379 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3219443 0.91 PLAT (0.43) PDE4DMAPTPOLBKDM4EPLAT
SCHEMBL3222801 0.81 PDE4D (0.41) PDE4DMAPTPOLBKDM4EADORA3
SCHEMBL2172464 0.77 PLAT (0.43) PDE4DMAPTPOLBKDM4EKMT2A
SCHEMBL14684504 0.75 PDE4D (0.36) PDE4DMAPTPOLBKDM4EADORA3
SCHEMBL3203987 0.71 ALDH1A1 (0.46) MAPTPOLBKDM4EKMT2AALDH1A1
SCHEMBL3216758 0.71 ADORA3 (0.34) PDE4DMAPTPOLBKDM4EKMT2A
SCHEMBL3216185 0.70 KDM4E (0.41) POLBKDM4EPLATALDH1A1HPGD
SCHEMBL3218428 0.70 PDE4B (0.32) PDE4DMAPTKDM4EKMT2A
SCHEMBL2171031 0.70 PDE4B (0.57) PDE4DPOLBKDM4EPLATALDH1A1
SCHEMBL3226056 0.69 PDE4D (0.37) PDE4DMAPTPOLBKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7763617-B2 Pyrazolopyridine-4-yl pyridazinone derivatives and addition salts thereof, and PDE inhibitors comprising the same derivatives or salts as active ingredient KYORIN PHARMACEUTICAL CO., LTD. (JP) 2010-07-27 — — US disclosed
US-7763617-B2 Pyrazolopyridine-4-yl pyridazinone derivatives and addition salts thereof, and PDE inhibitors comprising the same derivatives or salts as active ingredient KYORIN PHARMACEUTICAL CO., LTD. (JP) 2010-07-27 — — US disclosed
US-20080207902-A1 Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and Pde Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient KYORIN PHARMACEUTICAL CO., LTD. (JP) 2008-08-28 — — US disclosed
US-20080207902-A1 Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and Pde Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient KYORIN PHARMACEUTICAL CO., LTD. (JP) 2008-08-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080207902-A1 Pyrazolopyridine-4-Yl Pyridazinone Derivatives and Addition Salts Thereof, and Pde Inhibitors Comprising the Same Derivatives or Salts as Active Ingredient PDE5A, PDE3A, PDE3B PDE4D 9/4885MAPT 3621/4885POLB 2050/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.