Sugi Predict

Sugi Predict / Compounds / SCHEMBL29675736

SCHEMBL29675736

SCHEMBL29675736

CCC(=O)N[C@H](C)c1cccc(N(C)C)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACACB O00763 3/20 0.40
▸ MAPK1 P28482 2/20 0.38
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ MAPT P10636 2/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ TEAD4 Q15561 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HTT P42858 1/20 0.34
▸ ACACA Q13085 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PARP1 P09874 2/20 0.34
▸ PIN1 Q13526 1/20 0.34
▸ PARP3 Q9Y6F1 1/20 0.34
▸ KCNB1 Q14721 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29676186 0.84 ACACB (0.48) ACACBMAPK1ALDH1A1ACACA
SCHEMBL23343856 0.83 MAPK1 (0.40) ACACBMAPK1NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL29676873 0.82 MAPK1 (0.39) ACACBMAPK1NPC1RAB9AMAPT
SCHEMBL29676835 0.79 MAPK1 (0.38) ACACBMAPK1RAB9AMAPTALDH1A1
SCHEMBL29676379 0.78 MAPK1 (0.38) ACACBMAPK1NPC1RAB9AL3MBTL1
SCHEMBL29675844 0.77 CACNA1C (0.42) ACACBMAPK1NPC1RAB9AL3MBTL1
SCHEMBL29675850 0.77 RAB9A (0.42) ACACBMAPK1NPC1RAB9AL3MBTL1
SCHEMBL29675751 0.76 NPSR1 (0.40) ACACBMAPK1NPC1RAB9AL3MBTL1
SCHEMBL29675849 0.76 HTR7 (0.48) ACACBMAPK1ALDH1A1ACACAKCNB1
SCHEMBL30226095 0.75 ACACB (0.39) ACACBMAPK1NPC1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108617166-B Protein kinase inhibitor benzolactam compounds 大冢制药株式会社 2022-05-17 — — CN claimed
US-20240368136-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-11-07 — — US disclosed
US-11939321-B2 Benzolactam compounds as protein kinase inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-03-26 — — US disclosed
US-20230019032-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-01-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11939321-B2 Benzolactam compounds as protein kinase inhibitors MAPK1, ALK, MAP3K1 ACACB 3916/4885MAPK1 1/4885NPC1 2619/4885
US-20230019032-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS MAPK1, ALK, MAP3K1 ACACB 3916/4885MAPK1 1/4885NPC1 2619/4885
US-20240368136-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS MAPK1, ALK, MAP3K1 ACACB 3918/4885MAPK1 1/4885NPC1 2623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.