Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041840 | 1.00 | TGFBR1 (1.00) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL29676957 | 0.91 | TGFBR1 (0.83) | TGFBR1FGFR1JAK2PRKD3MAP4K4 | |
| SCHEMBL18041560 | 0.91 | TGFBR1 (0.83) | TGFBR1FGFR1JAK2PRKD3MAP4K4 | |
| SCHEMBL29677075 | 0.89 | TGFBR1 (0.80) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL18042039 | 0.89 | TGFBR1 (0.80) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL29677101 | 0.84 | TGFBR1 (0.72) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL18042033 | 0.84 | TGFBR1 (0.72) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL18041731 | 0.82 | TGFBR1 (0.69) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL29677104 | 0.82 | TGFBR1 (0.69) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 | |
| SCHEMBL29676967 | 0.82 | TGFBR1 (0.76) | TGFBR1FGFR1TGFBR2FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352360-B2 | TGF-beta inhibitors | Rigel Pharmaceuticals, hic. (US) | 2022-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352360-B2 | TGF-beta inhibitors | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885FGFR1 120/4885TGFBR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.