Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1192514 | 1.00 | POLB (0.38) | POLBATMHTTIDO1ALDH1A1 | |
| SCHEMBL20838797 | 1.00 | POLB (0.38) | POLBATMHTTIDO1ALDH1A1 | |
| SCHEMBL1192515 | 1.00 | POLB (0.38) | POLBATMHTTIDO1ALDH1A1 | |
| SCHEMBL20605467 | 0.92 | IDO1 (0.34) | POLBHTTIDO1ALDH1A1MAPT | |
| SCHEMBL20605383 | 0.88 | POLB (0.35) | POLBHTTIDO1ALDH1A1KMT2A | |
| SCHEMBL22619977 | 0.88 | POLB (0.35) | POLBHTTIDO1ALDH1A1KMT2A | |
| SCHEMBL28842000 | 0.85 | ALDH1A1 (0.37) | POLBHTTALDH1A1GAA | |
| SCHEMBL28841998 | 0.85 | ALDH1A1 (0.37) | POLBHTTALDH1A1GAA | |
| SCHEMBL28841996 | 0.84 | MAPT (0.32) | POLBHTTALDH1A1MAPT | |
| SCHEMBL14536912 | 0.82 | IDO1 (0.52) | IDO1ALDH1A1MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114886853-A | Solid dispersions of ErbB2(HER2) inhibitors | 阵列生物制药公司 | 2022-08-12 | — | — | CN | claimed |
| CN-114886853-A | Solid dispersions of ErbB2(HER2) inhibitors | 阵列生物制药公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-108498465-B | Solid dispersions of an ErbB2(HER2) inhibitor | 阵列生物制药公司 | 2022-05-17 | — | — | CN | disclosed |