Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.83 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041589 | 1.00 | TGFBR1 (0.83) | TGFBR1FGFR1EGFRFGFR2TGFBR2 | |
| SCHEMBL18041471 | 0.92 | TGFBR1 (0.70) | TGFBR1EGFRMAP4K4MAPK9CSNK1D | |
| SCHEMBL29677094 | 0.91 | TGFBR1 (1.00) | TGFBR1FGFR1EGFRFGFR2TGFBR2 | |
| SCHEMBL18041642 | 0.91 | TGFBR1 (1.00) | TGFBR1FGFR1EGFRFGFR2TGFBR2 | |
| SCHEMBL18042044 | 0.86 | TGFBR1 (0.78) | TGFBR1FGFR1EGFRFGFR2MAP4K4 | |
| SCHEMBL29677111 | 0.86 | TGFBR1 (0.78) | TGFBR1FGFR1EGFRFGFR2MAP4K4 | |
| SCHEMBL29677143 | 0.84 | TGFBR1 (0.61) | TGFBR1FGFR1FGFR2TGFBR2CSNK1D | |
| SCHEMBL18042030 | 0.84 | TGFBR1 (0.61) | TGFBR1FGFR1FGFR2TGFBR2CSNK1D | |
| SCHEMBL18041819 | 0.83 | TGFBR1 (0.70) | TGFBR1FGFR1EGFRFGFR2TGFBR2 | |
| SCHEMBL29677020 | 0.83 | TGFBR1 (0.70) | TGFBR1FGFR1EGFRFGFR2TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352360-B2 | TGF-beta inhibitors | Rigel Pharmaceuticals, hic. (US) | 2022-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352360-B2 | TGF-beta inhibitors | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885FGFR1 120/4885EGFR 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.