Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.83 |
| ▸ | KDR | P35968 | 4/20 | 0.83 |
| ▸ | FBP1 | P09467 | 2/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.83 |
| ▸ | AURKA | O14965 | 1/20 | 0.83 |
| ▸ | INSR | P06213 | 1/20 | 0.83 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.83 |
| ▸ | FLT4 | P35916 | 1/20 | 0.83 |
| ▸ | CLK1 | P49759 | 1/20 | 0.83 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.83 |
| ▸ | TEK | Q02763 | 1/20 | 0.83 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.83 |
| ▸ | RAF1 | P04049 | 1/20 | 0.76 |
| ▸ | BRAF | P15056 | 1/20 | 0.76 |
| ▸ | RET | P07949 | 2/20 | 0.72 |
| ▸ | KIF5B | P33176 | 2/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.72 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.68 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383 | 1.00 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL30124192 | 1.00 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| Hydrochloric Acid SCHEMBL28040041 | 0.99 | EGFR (0.81) | EGFRKDRFBP1ERBB2AURKA | |
| Hydrochloric Acid SCHEMBL27915151 | 0.98 | EGFR (0.80) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL3238800 | 0.96 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| Acetic Acid SCHEMBL29234690 | 0.95 | EGFR (0.75) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL13006609 | 0.93 | EGFR (0.71) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL14515606 | 0.91 | KDR (0.72) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL2099106 | 0.91 | EGFR (1.00) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL30505605 | 0.91 | EGFR (1.00) | EGFRKDRFBP1ERBB2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119119014-A | Small-molecule fluorescent photosensitizer containing gefitinib skeleton structure and AIE group, preparation and application thereof | 北京理工大学 | 2024-12-13 | — | — | CN | claimed |
| CN-118063399-A | Method for synthesizing N- (3-chloro-4-fluorophenyl) -6-hydroxy-7-methoxy-4-quinazolinamine | 杭州微流汇科技有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-117050025-A | Gefitinib derivative and preparation method thereof | 川北医学院 | 2023-11-14 | — | — | CN | claimed |
| CN-111253311-B | Preparation and application of aggregation-induced emission compound based on naphthalimide | 中国科学院大连化学物理研究所 | 2022-07-22 | — | — | CN | claimed |
| EP-4612149-A1 | PYRIDO[2,3-D]PYRIMIDIN-2-AMINE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| EP-4587017-A2 | HYDROXYLAMINE-BASED EGFR INHIBITORS FOR TREATMENT OF CANCER WITH BRAIN METASTASES | University of Georgia Research Foundation, Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| CN-119894510-A | Hydroxylamine-based EGFR inhibitors for the treatment of brain metastasis | 乔治亚大学研究基金会 | 2025-04-25 | — | — | CN | disclosed |
| CN-119119014-A | Small-molecule fluorescent photosensitizer containing gefitinib skeleton structure and AIE group, preparation and application thereof | 北京理工大学 | 2024-12-13 | — | — | CN | disclosed |
| CN-118063399-A | Method for synthesizing N- (3-chloro-4-fluorophenyl) -6-hydroxy-7-methoxy-4-quinazolinamine | 杭州微流汇科技有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-118063399-A | Method for synthesizing N- (3-chloro-4-fluorophenyl) -6-hydroxy-7-methoxy-4-quinazolinamine | 杭州微流汇科技有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-118063399-A | Method for synthesizing N- (3-chloro-4-fluorophenyl) -6-hydroxy-7-methoxy-4-quinazolinamine | 杭州微流汇科技有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-115611910-A | Preparation method of aminoquinazoline compound | 广东东阳光药业有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-115616216-A | Use of an agent that inhibits or blocks the interaction between FAAH and NLRP3 | 华南理工大学 | 2023-01-17 | — | — | CN | disclosed |
| CN-112125890-B | Isoindolinone-based quinazoline-based carboxylic ester derivative and application thereof | 华东理工大学 | 2022-12-06 | — | — | CN | disclosed |
| CN-113004251-B | Quinazoline derivative containing 2-nitroimidazole and application thereof | 郑州大学第一附属医院 | 2022-09-27 | — | — | CN | disclosed |
| CN-111253311-B | Preparation and application of aggregation-induced emission compound based on naphthalimide | 中国科学院大连化学物理研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111253311-B | Preparation and application of aggregation-induced emission compound based on naphthalimide | 中国科学院大连化学物理研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-112321566-B | EGFR protein degradation agent and anti-tumor application thereof | 上海科技大学 | 2022-06-10 | — | — | CN | disclosed |
| CN-112608302-B | Quinazoline derivative for activating target ubiquitination degradation of EGFR protein through low-oxygen reduction and application thereof | 郑州大学第一附属医院 | 2022-05-24 | — | — | CN | disclosed |