Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.71 |
| ▸ | KDR | P35968 | 4/20 | 0.71 |
| ▸ | FBP1 | P09467 | 2/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.71 |
| ▸ | INSR | P06213 | 1/20 | 0.71 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.71 |
| ▸ | FLT4 | P35916 | 1/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.71 |
| ▸ | TEK | Q02763 | 1/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.71 |
| ▸ | RAF1 | P04049 | 1/20 | 0.66 |
| ▸ | BRAF | P15056 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | KIF5B | P33176 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.59 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30124192 | 0.93 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL8383 | 0.93 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL29679736 | 0.93 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| Hydrochloric Acid SCHEMBL28040041 | 0.92 | EGFR (0.81) | EGFRKDRFBP1ERBB2AURKA | |
| Hydrochloric Acid SCHEMBL27915151 | 0.91 | EGFR (0.80) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL3238800 | 0.88 | EGFR (0.83) | EGFRKDRFBP1ERBB2AURKA | |
| Acetic Acid SCHEMBL29234690 | 0.88 | EGFR (0.75) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL3238953 | 0.86 | FBP1 (0.84) | EGFRKDRFBP1ERBB2AURKA | |
| SCHEMBL13006602 | 0.85 | EGFR (0.71) | EGFRKDRFBP1ERBB2AURKA | |
| Hydrochloric Acid SCHEMBL3722776 | 0.84 | EGFR (0.70) | EGFRKDRFBP1ERBB2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855204-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20100143295-A1 | QUINAZOLINE INHIBITORS OF EGFR TYROSINE KINASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | ABL1, EGFR, ERBB2 | EGFR 2/4885KDR 108/4885FBP1 3213/4885 |
| US-20100143295-A1 | QUINAZOLINE INHIBITORS OF EGFR TYROSINE KINASE | EGFR, ABL1, ERBB2 | EGFR 1/4885KDR 82/4885FBP1 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.