Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24532865 | 1.00 | MAPT (0.42) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL24532730 | 0.96 | MET (0.44) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL29681579 | 0.87 | LMNA (0.43) | SMN1; SMN2MEN1KMT2AMETALDH1A1 | |
| SCHEMBL24532812 | 0.87 | LMNA (0.43) | SMN1; SMN2MEN1KMT2AMETALDH1A1 | |
| SCHEMBL24532477 | 0.85 | MAPT (0.41) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL29681511 | 0.85 | MAPT (0.41) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL24532144 | 0.85 | MAPT (0.44) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL24532139 | 0.85 | IP6K1 (0.47) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL24532853 | 0.84 | MAPT (0.50) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL24532461 | 0.84 | MAPT (0.41) | MAPTSMN1; SMN2NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263535-A1 | N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)- QUINOLINE-4-CARBOXAMIDES | Astrazeneca AB (SE) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022130270-A1 | N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)- QUINOLINE-4-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2022-06-23 | — | — | WO | disclosed |