Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tacrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 1.00 |
| ▸ | BCHE known ✓ | P06276 | 8/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | CACNB4 | O00305 | 1/20 | 1.00 |
| ▸ | CACNA1A | O00555 | 1/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | CACNA1G | O43497 | 1/20 | 1.00 |
| ▸ | CACNG3 | O60359 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | CACNA1H | O95180 | 1/20 | 1.00 |
| ▸ | APP | P05067 | 1/20 | 1.00 |
| ▸ | FABP1 | P07148 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tacrine SCHEMBL7714835 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL29594645 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL2828 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL9407893 | 0.98 | CYP1A2 (0.97) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL8000475 | 0.98 | ACHE (0.97) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL7638777 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| SCHEMBL12043403 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL3270 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL14236722 | 0.98 | ACHE (0.97) | ACHEBCHETSHRHSD17B10ALDH1A1 | |
| Tacrine SCHEMBL1044163 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116102495-B | 1,2,3, 4-Tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | claimed |
| CN-116102495-A | 1,2,3, 4-tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2023-05-12 | — | — | CN | claimed |
| CN-116102495-B | 1,2,3, 4-Tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-116102495-B | 1,2,3, 4-Tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-116102495-B | 1,2,3, 4-Tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2025-03-21 | — | — | CN | disclosed |
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | WASHINGTON UNIVERSITY (US) | 2025-03-11 | — | — | US | disclosed |
| EP-4440621-A1 | PEPTIDE-DRUG CONJUGATES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | Københavns Universitet (DK) | 2024-10-09 | — | — | EP | disclosed |
| CN-118510545-A | Peptide-drug conjugates for the treatment of neurodegenerative diseases | 哥本哈根大学 | 2024-08-16 | — | — | CN | disclosed |
| CN-113603684-B | 1,2, 4-oxadiazole Nrf2 activator-tac Lin Pinge product and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | WASHINGTON UNIVERSITY | 2023-08-31 | — | — | US | disclosed |
| WO-2023127600-A1 | DRUG FOR TREATING SITH-1-ASSOCIATED DISEASES | 株式会社ウイルス医科学研究所 | 2023-07-06 | — | — | WO | disclosed |
| WO-2023099723-A1 | PEPTIDE-DRUG CONJUGATES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | Københavns Universitet (DK) | 2023-06-08 | — | — | WO | disclosed |
| CN-116102495-A | 1,2,3, 4-tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2023-05-12 | — | — | CN | disclosed |
| CN-116102495-A | 1,2,3, 4-tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2023-05-12 | — | — | CN | disclosed |
| CN-116102495-A | 1,2,3, 4-tetrahydro-9-aminoacridine compound and application thereof | 浙江工业大学 | 2023-05-12 | — | — | CN | disclosed |
| CN-114588180-B | Application of gallnut ethanol extract and fraxinin in preparation of medicine for treating attention deficit hyperactivity disorder | 金相希 | 2023-04-28 | — | — | CN | disclosed |
| CN-113194972-B | Application of gallnut ethanol extract and aesculin in preparation of medicine for improving cognitive ability and preventing or treating dementia | 金相希 | 2022-09-16 | — | — | CN | disclosed |
| CN-114588180-A | Composition for preventing or treating attention deficit hyperactivity disorder | 金相希 | 2022-06-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230272449-A1 | IDENTIFICATION OF INHIBITORS OF TCPC AND TIR NADase ACTIVITY | NADK, NAPRT, TIPARP | ACHE 3265/4885BCHE 2678/4885TSHR 2861/4885 |
| US-12247246-B2 | Identification of inhibitors of TcpC and TIR NADase activity | NADK, NAPRT, TIPARP | ACHE 3265/4885BCHE 2678/4885TSHR 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.