Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tacrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 1.00 |
| ▸ | BCHE known ✓ | P06276 | 14/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.97 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.97 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.97 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.97 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.97 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tacrine SCHEMBL2330283 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2330285 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL1044163 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL490750 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL7638777 | 1.00 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2236694 | 0.98 | THRB (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL5580054 | 0.98 | THRB (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL29681895 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL29594645 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2828 | 0.98 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11998 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-20250333435-A1 | TIMOSAPONIN COMPOUNDS | GOLDPORP PHARMA LTD (CN) | 2025-10-30 | — | — | US | claimed |
| US-20250214984-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-07-03 | — | — | US | claimed |
| EP-4146645-B1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO PHARMACEUTICAL CO (JP) | 2025-06-25 | — | — | EP | claimed |
| US-12234258-B2 | Timosaponin compounds | GOLDPORP PHARMA LIMITED (CN) | 2025-02-25 | — | — | US | claimed |
| US-12227500-B2 | Substituted pyrrolo[2,3-b]pyridines for suppressing toxic endoplasmic reticulum stress | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-02-18 | — | — | US | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-4471027-A1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2024-12-04 | — | — | EP | claimed |
| US-20240156790-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2024-05-16 | — | — | US | claimed |
| US-20240117025-A1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS BY INTRANASAL ADMINISTRATION OF IMMUNOGLOBULIN G | Baxalta GmbH (CH) | 2024-04-11 | — | — | US | claimed |
| US-5698224-A | Tacrine therapy | ALZA CORPORATION (US) | 1997-12-16 | — | — | US | claimed |
| EP-0760098-A4 | DIAGNOSIS OF ALZHEIMER DISEASE STAGE BY MONONUCLEAR CELL CYTOKINE SECRETIONS | UNIV BAR ILAN (IL) | 1997-07-16 | — | — | EP | claimed |
| EP-0768880-A1 | TACRINE PHARMACEUTICAL COMPOSITIONS | ALZA CORPORATION (US) | 1997-04-23 | — | — | EP | claimed |
| EP-0760098-A1 | DIAGNOSIS OF ALZHEIMER DISEASE STAGE BY MONONUCLEAR CELL CYTOKINE SECRETIONS | BAR-ILAN UNIVERSITY (IL) | 1997-03-05 | — | — | EP | claimed |
| EP-0746342-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD. (US) | 1996-12-11 | — | — | EP | claimed |
| US-5518730-A | Biodegradable controlled release flash flow melt-spun delivery system | FUISZ TECHNOLOGIES LTD. (US) | 1996-05-21 | — | — | US | claimed |
| EP-0746342-A4 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD (US) | 1996-01-11 | — | — | EP | claimed |
| WO-1996000065-A1 | TACRINE PHARMACEUTICAL COMPOSITIONS | ALZA CORPORATION (US) | 1996-01-04 | — | — | WO | claimed |
| WO-1995033992-A1 | DIAGNOSIS OF ALZHEIMER DISEASE STAGE BY MONONUCLEAR CELL CYTOKINE SECRETIONS | BAR-ILAN UNIVERSITY (IL) | 1995-12-14 | — | — | WO | claimed |
| WO-1993024154-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES, LTD. (US) | 1993-12-09 | — | — | WO | claimed |