Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24542419 | 1.00 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL24231689 | 0.81 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL29373972 | 0.81 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL29682996 | 0.79 | DYRK1A (0.38) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL24542626 | 0.79 | DYRK1A (0.38) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL24542406 | 0.78 | FLT3 (0.42) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL24231440 | 0.77 | EIF2AK4 (0.47) | GABRA1GABRG2GABRB3GABRA3FLT3 | |
| SCHEMBL29373301 | 0.77 | EIF2AK4 (0.47) | GABRA1GABRG2GABRB3GABRA3FLT3 | |
| SCHEMBL24542764 | 0.77 | IRAK4 (0.60) | FLT3KDRIRAK4 | |
| SCHEMBL24542587 | 0.77 | FLT3 (0.46) | FLT3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262802-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-116887834-A | Polycyclic IRAK and flt3 inhibiting compounds and uses thereof | 儿童医院医学中心 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022132936-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-06-23 | — | — | WO | disclosed |