Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043993 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP3A4KDM4EHDAC4HDAC7 | |
| SCHEMBL23462029 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4KDM4EHDAC4HDAC7 | |
| SCHEMBL29975353 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP3A4KDM4EHDAC4HDAC7 | |
| SCHEMBL17724503 | 0.83 | KDM4E (0.60) | ALDH1A1KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL23042908 | 0.83 | ALDH1A1 (0.42) | ALDH1A1CYP3A4KDM4ECES2CES1 | |
| SCHEMBL31736106 | 0.83 | ALDH1A1 (0.42) | ALDH1A1CYP3A4KDM4ECES2CES1 | |
| SCHEMBL11350399 | 0.82 | CYP3A4 (0.50) | ALDH1A1CYP3A4HSD17B10TSHRLMNA | |
| SCHEMBL1286155 | 0.81 | ALDH1A1 (0.70) | ALDH1A1CYP3A4KDM4EHSD17B10TSHR | |
| SCHEMBL628737 | 0.81 | ALDH1A1 (0.70) | ALDH1A1CYP3A4KDM4EHSD17B10TSHR | |
| SCHEMBL493954 | 0.81 | ALDH1A1 (0.70) | ALDH1A1CYP3A4KDM4EHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473296-B2 | Perk inhibiting compounds | HIBERCELL, INC. (US) | 2025-11-18 | — | — | US | disclosed |
| US-12331054-B2 | Perk inhibiting imidazolopyrazine compounds | HIBERCELL, INC. (US) | 2025-06-17 | — | — | US | disclosed |
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | HIBERCELL, INC. | 2022-11-10 | — | — | US | disclosed |
| US-20220348583-A1 | PERK INHIBITING IMIDAZOLOPYRAZINE COMPOUNDS | HIBERCELL, INC. | 2022-11-03 | — | — | US | disclosed |
| US-20220332722-A1 | PERK INHIBITING COMPOUNDS | HIBERCELL, INC. | 2022-10-20 | — | — | US | disclosed |
| CN-115003296-A | Compounds and methods for treating cystic fibrosis | 弗拉特利发现实验室有限责任公司 | 2022-09-02 | — | — | CN | disclosed |
| EP-4021908-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| EP-4021893-A1 | PERK INHIBITING COMPOUNDS | Hibercell, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-114710956-A | PERK-INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | 希伯塞尔股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114585606-A | PERK inhibiting compounds | 希伯塞尔股份有限公司 | 2022-06-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332722-A1 | PERK INHIBITING COMPOUNDS | ATF4, EEF2K, ERN1 | ALDH1A1 2734/4885CYP3A4 4465/4885KDM4E 2977/4885 |
| US-20220356186-A1 | PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS | EEF2K, ATF4, MAPKAPK2 | ALDH1A1 2477/4885CYP3A4 3991/4885KDM4E 2321/4885 |
| US-20220348583-A1 | PERK INHIBITING IMIDAZOLOPYRAZINE COMPOUNDS | MAPKAPK2, MAPK4, MAP3K5 | ALDH1A1 2619/4885CYP3A4 3599/4885KDM4E 3007/4885 |
| US-12331054-B2 | Perk inhibiting imidazolopyrazine compounds | MAPKAPK2, MAPK4, MAP3K5 | ALDH1A1 2619/4885CYP3A4 3599/4885KDM4E 3007/4885 |
| US-12473296-B2 | Perk inhibiting compounds | MAPK1, ERN1, MAP3K20 | ALDH1A1 1102/4885CYP3A4 2620/4885KDM4E 2848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.