Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 7/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 3/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24455369 | 1.00 | GLP1R (0.48) | GLP1RPRMT5HTR2CHTR2AHTR2B | |
| SCHEMBL22993044 | 0.86 | GLP1R (0.46) | GLP1RKCNH2GPR119PRKCQ | |
| SCHEMBL20288052 | 0.85 | HTR3A (0.51) | GLP1RPRMT5HTR2CHTR2AHTR2B | |
| SCHEMBL24485826 | 0.85 | GLP1R (0.48) | GLP1RPRMT5HTR2CDRD2DRD3 | |
| SCHEMBL30149335 | 0.85 | GLP1R (0.48) | GLP1RPRMT5HTR2CDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL28973080 | 0.84 | HTR3A (0.50) | GLP1RPRMT5HTR2CHTR2AHTR2B | |
| SCHEMBL24485507 | 0.84 | GPR119 (0.43) | GLP1RHTR2CDRD2DRD3HTR1A | |
| SCHEMBL20266485 | 0.84 | GLP1R (0.51) | GLP1R | |
| SCHEMBL30149315 | 0.84 | GPR119 (0.43) | GLP1RHTR2CDRD2DRD3HTR1A | |
| SCHEMBL29574507 | 0.84 | GLP1R (0.51) | GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247804-A1 | POLYHETEROCYCLIC GLP-1 R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022109182-A9 | POLYHETEROCYCLIC GLP-1 R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022109182-A1 | POLYHETEROCYCLIC GLP-1 R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |