Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CDC42 | P60953 | 1/20 | 0.36 |
| ▸ | RAC1 | P63000 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16386818 | 0.79 | POLB (0.59) | POLBTSHRMAPTHPGDHSD17B10 | |
| SCHEMBL30824278 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1POLBTSHRMAPT | |
| SCHEMBL490436 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1POLBTSHRMAPT | |
| SCHEMBL195368 | 0.79 | POLB (0.55) | PTGS2PTGS1POLBTSHRMAPT | |
| SCHEMBL3678216 | 0.78 | PTGS2 (0.48) | PTGS2PTGS1POLBTSHRMAPT | |
| SCHEMBL24211162 | 0.76 | GAA (0.43) | POLBTSHRMAPTHPGDHSD17B10 | |
| SCHEMBL19182904 | 0.75 | PTGS2 (0.49) | PTGS2PTGS1TSHRAKR1C3AKR1C2 | |
| SCHEMBL31170887 | 0.75 | PTGS2 (0.49) | PTGS2PTGS1TSHRAKR1C3AKR1C2 | |
| SCHEMBL22457320 | 0.75 | PTGS2 (0.60) | PTGS2PTGS1TSHRAKR1C3AKR1C2 | |
| SCHEMBL22796714 | 0.73 | POLB (0.41) | POLBGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351577-B2 | Inhibiting cyclic AMP-responsive element-binding protein (CREB) | FORMA THERAPEUTICS, INC. (US) | 2025-07-08 | — | — | US | disclosed |
| US-20250188079-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | FORMA THERAPEUTICS, INC. | 2025-06-12 | — | — | US | disclosed |
| US-20220213089-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | FORMA THERAPEUTICS, INC. | 2022-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250188079-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | CREBBP, CREB1, EP300 | PTGS2 2496/4885PTGS1 1831/4885POLB 731/4885 |
| US-12351577-B2 | Inhibiting cyclic AMP-responsive element-binding protein (CREB) | CREBBP, CREB1, EP300 | PTGS2 2496/4885PTGS1 1831/4885POLB 731/4885 |
| US-20220213089-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | CREBBP, CREB1, EP300 | PTGS2 2496/4885PTGS1 1831/4885POLB 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.