Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23044427 | 1.00 | MAP4K4 (0.51) | MAP4K4EIF2AK3FEN1NOS3NOS2 | |
| SCHEMBL4502041 | 0.84 | EIF2AK3 (0.55) | MAP4K4EIF2AK3FEN1NOS3NOS2 | |
| SCHEMBL3813235 | 0.81 | NOS3 (0.52) | MAP4K4EIF2AK3FEN1NOS3NOS2 | |
| SCHEMBL17805365 | 0.81 | NOS3 (0.47) | MAP4K4EIF2AK3FEN1NOS3NOS2 | |
| SCHEMBL8146040 | 0.80 | ALDH1A1 (0.56) | PDE10AALDH1A1KDM4EGAA | |
| SCHEMBL17805344 | 0.79 | GAA (0.48) | MAP4K4EIF2AK3FEN1NOS3NOS2 | |
| SCHEMBL1256964 | 0.79 | PIK3CD (0.52) | MAP4K4FEN1MAP3K11PIK3CDMKNK1 | |
| SCHEMBL1256887 | 0.79 | FEN1 (0.63) | MAP4K4FEN1ALOX5APTDO2 | |
| SCHEMBL99566 | 0.78 | ALDH1A1 (0.54) | PDE10AALDH1A1KDM4EGAA | |
| SCHEMBL16681203 | 0.78 | NOS3 (0.52) | MAP4K4EIF2AK3FEN1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585606-A | PERK inhibiting compounds | 希伯塞尔股份有限公司 | 2022-06-03 | — | — | CN | disclosed |