Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 9/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 8/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23012269 | 1.00 | NLRP3 (0.38) | NLRP3ALDH2PTGDR2SCN8ASCN10A | |
| SCHEMBL29691334 | 0.87 | PTGDR2 (0.43) | NLRP3ALDH2PTGDR2 | |
| SCHEMBL23012433 | 0.87 | PTGDR2 (0.43) | NLRP3ALDH2PTGDR2 | |
| SCHEMBL23012726 | 0.78 | NLRP3 (0.47) | NLRP3 | |
| SCHEMBL29691373 | 0.78 | NLRP3 (0.47) | NLRP3 | |
| SCHEMBL22802403 | 0.76 | NLRP3 (0.55) | NLRP3 | |
| SCHEMBL22802365 | 0.73 | GAA (0.40) | NLRP3 | |
| SCHEMBL22996918 | 0.72 | LPAR1 (0.39) | NLRP3 | |
| SCHEMBL23012955 | 0.71 | NLRP3 (0.51) | NLRP3PTGDR2 | |
| SCHEMBL29691371 | 0.71 | NLRP3 (0.51) | NLRP3PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013762-A1 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | Inflazome Limited (IE) | 2022-06-22 | — | — | EP | disclosed |
| CN-114555609-A | Macrocyclic sulfonamide derivatives useful as NLRP3 inhibitors | 英夫拉索姆有限公司 | 2022-05-27 | — | — | CN | disclosed |