Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | RXRB | P28702 | 3/20 | 0.40 |
| ▸ | RXRG | P48443 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17189661 | 1.00 | DRD2 (0.44) | DRD2DRD1TBXA2RDRD4DRD5 | |
| SCHEMBL17189662 | 0.88 | HCRTR1 (0.41) | OPRM1RXRARXRBRXRGFFAR4 | |
| SCHEMBL16585096 | 0.84 | OPRM1 (0.41) | OPRM1GAAPPARGPPARDPPARA | |
| SCHEMBL16585095 | 0.84 | OPRM1 (0.41) | OPRM1GAAPPARGPPARDPPARA | |
| SCHEMBL1208921 | 0.80 | HTR2A (0.50) | DRD2DRD1TBXA2RDRD4DRD5 | |
| SCHEMBL17103923 | 0.80 | HTR2A (0.50) | DRD2DRD1TBXA2RDRD4DRD5 | |
| SCHEMBL2961132 | 0.79 | NR1I2 (0.45) | DRD2DRD1TBXA2RDRD4DRD5 | |
| SCHEMBL324565 | 0.76 | EPHX2 (0.51) | FFAR1RXRARXRBRXRGEPHX2 | |
| SCHEMBL324564 | 0.76 | EPHX2 (0.51) | FFAR1RXRARXRBRXRGEPHX2 | |
| SCHEMBL19834337 | 0.76 | TSHR (0.41) | OPRM1RXRARXRBRXRGFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | disclosed |
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-10-15 | — | — | US | disclosed |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | DRD2 2684/4885DRD1 2160/4885TBXA2R 1472/4885 |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | DRD2 2890/4885DRD1 2515/4885TBXA2R 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.