Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.77 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.77 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | RAB9A | P51151 | 1/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.70 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485374 | 0.93 | GPBAR1 (0.80) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL14485352 | 0.92 | GPBAR1 (0.85) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL30132731 | 0.91 | GPBAR1 (0.83) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL19577573 | 0.90 | GPBAR1 (0.81) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL17430857 | 0.90 | GPBAR1 (0.81) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL19577558 | 0.90 | GPBAR1 (0.81) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL23312339 | 0.89 | GPBAR1 (0.80) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL1653681 | 0.89 | GPBAR1 (0.80) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL15467319 | 0.89 | GPBAR1 (0.85) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A | |
| SCHEMBL18280271 | 0.89 | GPBAR1 (0.85) | GPBAR1SLC10A2SLC10A1ABCB11KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116660543-A | Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof | 中国人民解放军陆军军医大学第一附属医院 | 2023-08-29 | — | — | CN | claimed |
| US-20240350562-A1 | Bile Acids and Use in Disease Treatment | UNIV CALIFORNIA (US) | 2024-10-24 | — | — | US | disclosed |
| US-11980645-B2 | Bile acids and use in disease treatment | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-05-14 | — | — | US | disclosed |
| CN-116549488-A | A pharmaceutical preparation for preventing liver fibrosis and protecting liver, and its preparation method | 五邑大学 | 2023-08-08 | — | — | CN | disclosed |
| US-20220202881-A1 | Bile Acids and Use in Disease Treatment | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220202881-A1 | Bile Acids and Use in Disease Treatment | SLC10A2, NR1H4, GPBAR1 | GPBAR1 3/4885SLC10A2 1/4885SLC10A1 4/4885 |
| US-11980645-B2 | Bile acids and use in disease treatment | SLC10A2, NR1H4, GPBAR1 | GPBAR1 3/4885SLC10A2 1/4885SLC10A1 4/4885 |
| US-20240350562-A1 | Bile Acids and Use in Disease Treatment | SLC10A2, NR1H4, GPBAR1 | GPBAR1 3/4885SLC10A2 1/4885SLC10A1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.