Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.88 |
| ▸ | MET | P08581 | 11/20 | 0.88 |
| ▸ | KDR | P35968 | 5/20 | 0.88 |
| ▸ | MERTK | Q12866 | 6/20 | 0.82 |
| ▸ | RET | P07949 | 3/20 | 0.72 |
| ▸ | KIT | P10721 | 3/20 | 0.72 |
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.72 |
| ▸ | FLT1 | P17948 | 4/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.71 |
| ▸ | AURKA | O14965 | 2/20 | 0.71 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.71 |
| ▸ | ABL1 | P00519 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 2/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.71 |
| ▸ | LCK | P06239 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372296 | 1.00 | AXL (0.88) | AXLMETKDRMERTKRET | |
| SCHEMBL29693534 | 1.00 | AXL (0.88) | AXLMETKDRMERTKRET | |
| SCHEMBL29693516 | 0.96 | AXL (0.88) | AXLMETKDRMERTKRET | |
| SCHEMBL4401190 | 0.96 | AXL (0.88) | AXLMETKDRMERTKRET | |
| Exelixis SCHEMBL29693473 | 0.94 | MET (1.00) | AXLMETKDRMERTKRET | |
| Exelixis SCHEMBL371899 | 0.94 | MET (1.00) | AXLMETKDRMERTKRET | |
| SCHEMBL21260785 | 0.93 | MET (0.82) | AXLMETKDRMERTKRET | |
| SCHEMBL21201030 | 0.90 | AXL (0.87) | AXLMETKDRMERTKRET | |
| SCHEMBL21200712 | 0.90 | AXL (1.00) | AXLMETKDRMERTKRET | |
| SCHEMBL30152581 | 0.90 | AXL (0.87) | AXLMETKDRMERTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | claimed |