Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 13/20 | 0.83 |
| ▸ | MET | P08581 | 10/20 | 0.83 |
| ▸ | KDR | P35968 | 4/20 | 0.83 |
| ▸ | MERTK | Q12866 | 5/20 | 0.81 |
| ▸ | FLT1 | P17948 | 3/20 | 0.81 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.81 |
| ▸ | RET | P07949 | 2/20 | 0.81 |
| ▸ | KIT | P10721 | 2/20 | 0.81 |
| ▸ | FLT3 | P36888 | 2/20 | 0.81 |
| ▸ | AURKA | O14965 | 1/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.81 |
| ▸ | ABL1 | P00519 | 1/20 | 0.81 |
| ▸ | EGFR | P00533 | 1/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.81 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.81 |
| ▸ | LCK | P06239 | 1/20 | 0.81 |
| ▸ | PGR | P06401 | 1/20 | 0.81 |
| ▸ | LYN | P07948 | 1/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372199 | 1.00 | AXL (0.83) | AXLMETKDRMERTKFLT1 | |
| SCHEMBL19373328 | 0.94 | AXL (0.73) | AXLMETKDRMERTKFLT1 | |
| SCHEMBL19372985 | 0.92 | AXL (0.71) | AXLMETKDRMERTKFLT1 | |
| SCHEMBL5141878 | 0.91 | AXL (0.76) | AXLMETKDRMERTKFLT1 | |
| Exelixis SCHEMBL371899 | 0.91 | MET (1.00) | AXLMETKDRMERTKFLT1 | |
| Exelixis SCHEMBL29693473 | 0.91 | MET (1.00) | AXLMETKDRMERTKFLT1 | |
| SCHEMBL29693417 | 0.90 | AXL (0.75) | AXLMETKDRMERTKFLT1 | |
| SCHEMBL371824 | 0.90 | AXL (0.75) | AXLMETKDRMERTKFLT1 | |
| SCHEMBL15338455 | 0.90 | AXL (0.68) | AXLMETKDRMERTKFLT1 | |
| Cabozantinib SCHEMBL29351408 | 0.90 | AXL (1.00) | AXLMETKDRMERTKFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | claimed |