Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.78 |
| ▸ | FLT1 | P17948 | 6/20 | 0.78 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.78 |
| ▸ | EGFR | P00533 | 8/20 | 0.76 |
| ▸ | RET | P07949 | 7/20 | 0.76 |
| ▸ | KIF5B | P33176 | 6/20 | 0.76 |
| ▸ | FLT4 | P35916 | 3/20 | 0.74 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.74 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | FBP1 | P09467 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.61 |
| ▸ | TEK | Q02763 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206623 | 1.00 | KDR (0.78) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL12510782 | 0.89 | KDR (0.62) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL7866068 | 0.86 | KDR (0.80) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL5864525 | 0.86 | KDR (1.00) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL15580162 | 0.85 | KDR (0.65) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL3012896 | 0.85 | KDR (1.00) | KDRFLT1FGFR1EGFRRET | |
| Hydrochloric Acid SCHEMBL7870586 | 0.85 | KDR (0.78) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL29365791 | 0.85 | KDR (1.00) | KDRFLT1FGFR1EGFRRET | |
| Hydrochloric Acid SCHEMBL7864775 | 0.85 | KDR (0.98) | KDRFLT1FGFR1EGFRRET | |
| SCHEMBL18158611 | 0.85 | KDR (0.82) | KDRFLT1FGFR1EGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |