Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.65 |
| ▸ | MET | P08581 | 5/20 | 0.62 |
| ▸ | EGFR | P00533 | 13/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.51 |
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | FLT4 | P35916 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371859 | 1.00 | AXL (0.65) | AXLMETEGFRPDPK1FGFR1 | |
| SCHEMBL5411428 | 0.90 | AXL (0.60) | AXLMETEGFRKDRFLT3 | |
| SCHEMBL15338423 | 0.90 | EGFR (0.63) | AXLMETEGFRFGFR1FLT1 | |
| SCHEMBL3544369 | 0.89 | MET (0.58) | AXLMETKDRFLT3 | |
| SCHEMBL2744533 | 0.88 | MET (0.60) | AXLMETEGFRFGFR1FLT1 | |
| SCHEMBL14313711 | 0.88 | MET (0.60) | AXLMETEGFRFGFR1FLT1 | |
| SCHEMBL371845 | 0.88 | AXL (0.61) | AXLMETEGFRFLT1KDR | |
| SCHEMBL371889 | 0.85 | MET (0.60) | AXLMETEGFRFGFR1FLT1 | |
| SCHEMBL20216820 | 0.85 | MET (0.66) | AXLMETEGFRFLT3PLK4 | |
| SCHEMBL168001 | 0.85 | AXL (0.54) | AXLMETKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |