Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | CCNC | P24863 | 2/20 | 0.56 |
| ▸ | CDK8 | P49336 | 2/20 | 0.56 |
| ▸ | POLQ | O75417 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29694990 | 0.88 | CDC7 (0.50) | PIK3CBCCNCCDK8POLQSIRT3 | |
| SCHEMBL29108196 | 0.86 | NNMT (0.54) | PIK3CBCCNCCDK8POLQDYRK1A | |
| SCHEMBL24501138 | 0.86 | POLQ (0.53) | PIK3CBCCNCCDK8POLQNFATC1 | |
| SCHEMBL30640140 | 0.86 | POLQ (0.53) | PIK3CBCCNCCDK8POLQNFATC1 | |
| SCHEMBL25307513 | 0.85 | PIK3CB (0.58) | PIK3CBCCNCCDK8POLQMAPK1 | |
| SCHEMBL31032177 | 0.82 | MKNK1 (0.59) | POLQSIRT3TDP1BTK | |
| SCHEMBL24500766 | 0.82 | POLQ (0.59) | PIK3CBCCNCCDK8POLQDYRK1A | |
| SCHEMBL30640199 | 0.82 | POLQ (0.59) | PIK3CBCCNCCDK8POLQDYRK1A | |
| SCHEMBL3989783 | 0.81 | PIK3CB (0.57) | PIK3CBCCNCCDK8CDC7 | |
| SCHEMBL27803074 | 0.78 | PIK3CB (0.53) | PIK3CBCCNCCDK8TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |
| EP-4255573-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |