Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 15/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 14/20 | 0.60 |
| ▸ | BCL2L11 | O43521 | 2/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | HEXA | P06865 | 1/20 | 0.50 |
| ▸ | HEXB | P07686 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28781801 | 0.78 | CYP1B1 (0.68) | HEXAHEXBCYP1B1KDM4EMEN1 | |
| SCHEMBL21501553 | 0.76 | BCL2 (0.62) | BCL2MCL1BCL2L11BCL2L1MEN1 | |
| SCHEMBL29695591 | 0.76 | BCL2 (1.00) | BCL2MCL1BCL2L11BCL2L1PLK1 | |
| SCHEMBL29695569 | 0.75 | BCL2 (1.00) | BCL2MCL1BCL2L11BCL2L1 | |
| SCHEMBL13964866 | 0.74 | USP2 (0.70) | HEXAHEXBCYP1B1KDM4EMEN1 | |
| SCHEMBL27461130 | 0.72 | KDM4E (0.68) | HEXAHEXBCYP1B1KDM4EMEN1 | |
| SCHEMBL28929152 | 0.72 | BCL2 (0.54) | BCL2MCL1BCL2L11BCL2L1PLK1 | |
| SCHEMBL11351614 | 0.72 | MEN1 (0.56) | BCL2MCL1BCL2L11PLK1CYP1B1 | |
| SCHEMBL30523864 | 0.70 | RAB9A (0.62) | BCL2MCL1BCL2L11PLK1CYP1B1 | |
| SCHEMBL2524513 | 0.70 | MCL1 (0.60) | BCL2MCL1BCL2L11BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025865-A1 | COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-01-26 | — | — | US | claimed |
| CN-114786654-A | Compositions and methods for systemic delivery of Bcl-2 and Bcl-xL antagonists | 密执安大学评议会 | 2022-07-22 | — | — | CN | claimed |
| US-20230025865-A1 | COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025865-A1 | COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF Bcl-2 AND Bcl-xL ANTAGONISTS | BCL2, BCL2L2, BCL2L1 | BCL2 1/4885MCL1 10/4885BCL2L11 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.