Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | KHK | P50053 | 2/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12295117 | 1.00 | NPSR1 (0.63) | NPSR1NPC1RAB9AKHKPSMB8 | |
| SCHEMBL31122583 | 1.00 | NPSR1 (0.63) | NPSR1NPC1RAB9AKHKPSMB8 | |
| SCHEMBL10326684 | 1.00 | NPSR1 (0.63) | NPSR1NPC1RAB9AKHKPSMB8 | |
| SCHEMBL17676960 | 1.00 | NPSR1 (0.63) | NPSR1NPC1RAB9AKHKPSMB8 | |
| SCHEMBL259395 | 0.96 | NPSR1 (0.66) | NPSR1NPC1RAB9AKHKPSMB8 | |
| SCHEMBL18591277 | 0.93 | NPSR1 (0.64) | NPSR1NPC1RAB9AKHKALDH1A1 | |
| SCHEMBL10326796 | 0.85 | LMNA (0.59) | NPSR1KHKPSMB8SCN9ALMNA | |
| SCHEMBL10327137 | 0.85 | LMNA (0.59) | NPSR1KHKPSMB8SCN9ALMNA | |
| SCHEMBL10106568 | 0.85 | LMNA (0.59) | NPSR1KHKPSMB8SCN9ALMNA | |
| SCHEMBL13976886 | 0.84 | PSMB8 (0.54) | NPSR1NPC1KHKPSMB8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010080-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2023-09-27 | — | — | EP | claimed |
| EP-4010080-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |