Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14428711 | 1.00 | GPR119 (0.42) | GPR119CHRM2CHRM1CHRM3ABCB1 | |
| SCHEMBL17037848 | 0.81 | CHRM2 (0.40) | GPR119CHRM2CHRM1CHRM3ABCB1 | |
| SCHEMBL30040501 | 0.81 | CNR1 (0.46) | GPR119CHRM2CHRM1CHRM3CNR1 | |
| SCHEMBL13138460 | 0.81 | NR1H2 (0.46) | GPR119CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL29865853 | 0.81 | CNR1 (0.46) | GPR119CHRM2CHRM1CHRM3CNR1 | |
| SCHEMBL30040477 | 0.80 | ALDH1A1 (0.46) | GPR119CHRM2CHRM1CHRM3STS | |
| SCHEMBL30039889 | 0.80 | ALDH1A1 (0.46) | GPR119CHRM2CHRM1CHRM3STS | |
| SCHEMBL13137753 | 0.80 | GPR119 (0.47) | GPR119CHRM2CHRM1CHRM3ABCB1 | |
| SCHEMBL14428713 | 0.79 | CHRM2 (0.38) | GPR119CHRM2CHRM1CHRM3CNR1 | |
| SCHEMBL22981185 | 0.79 | SMYD3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |