Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15882223 | 1.00 | NR1H2 (0.40) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL16741058 | 0.86 | NR1H2 (0.41) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL31346862 | 0.84 | ESR2 (0.38) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL2751778 | 0.84 | PREP (0.38) | NR1H2HTTATMESR2ALDH1A1 | |
| SCHEMBL4401573 | 0.83 | GPR119 (0.47) | NR1H2HTTATMGPR119MAPK1 | |
| SCHEMBL15882625 | 0.83 | SMN1; SMN2 (0.45) | — | |
| SCHEMBL4400858 | 0.82 | GPR119 (0.46) | NR1H2MAPTALDH1A1GPR119LMNA | |
| SCHEMBL15933470 | 0.82 | NR1H2 (0.41) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL1817445 | 0.81 | ADORA1 (0.42) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL14553991 | 0.81 | MGLL (0.43) | NR1H2HTTATMESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |