Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.53 |
| ▸ | CLK1 | P49759 | 7/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24588844 | 1.00 | DYRK1A (0.53) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL24773399 | 0.83 | DYRK1A (0.50) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL24588145 | 0.81 | CLK1 (0.53) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL29699138 | 0.81 | CLK1 (0.53) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL30439297 | 0.81 | CLK1 (0.73) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL29699079 | 0.81 | CLK1 (0.53) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL25600778 | 0.81 | CLK1 (0.73) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL24588201 | 0.81 | CLK1 (0.53) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL21596305 | 0.80 | IMPDH2 (0.49) | CLK1CDK5CDK5R1RPS6KA5CCNT1 | |
| SCHEMBL30261054 | 0.80 | IMPDH2 (0.49) | CLK1CDK5CDK5R1RPS6KA5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745277-A | Aromatic heterocyclic compound, pharmaceutical composition and application thereof | 湃隆生物科技有限公司（香港） | 2023-09-12 | — | — | CN | disclosed |
| WO-2022134642-A1 | AROMATIC HETEROCYCLIC COMPOUND, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 湃隆生物科技有限公司（香港） | 2022-06-30 | — | — | WO | disclosed |