Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.42 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | BLM | P54132 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371359 | 1.00 | CFTR (0.50) | CFTRPLAUMAPTKMT2AMEN1 | |
| SCHEMBL14631665 | 0.84 | CFTR (0.47) | CFTRPLAUMAPTKMT2AMEN1 | |
| SCHEMBL29699257 | 0.74 | CACNA1B (0.54) | CFTRMAPTKMT2AMEN1POLB | |
| SCHEMBL2372725 | 0.74 | CACNA1B (0.54) | CFTRMAPTKMT2AMEN1POLB | |
| SCHEMBL2371668 | 0.73 | PLAU (0.36) | CFTRPLAUMAPTALDH1A1KDM4E | |
| SCHEMBL2371983 | 0.71 | MAPT (0.46) | CFTRMAPTKMT2AMEN1POLB | |
| SCHEMBL22573733 | 0.71 | POLB (0.50) | PLAUMAPTKMT2AMEN1POLB | |
| SCHEMBL4584998 | 0.70 | ADORA2A (0.57) | PLAUMAPTKMT2AMEN1POLB | |
| SCHEMBL10374405 | 0.69 | ALDH1A1 (0.52) | CFTRPLAUMAPTKMT2AMEN1 | |
| SCHEMBL4584246 | 0.68 | ADORA2A (0.44) | PLAUMAPTKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |