Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11371593 | 0.74 | MET (0.48) | MAPTHSD17B10ALDH1A1POLBTDP1 | |
| SCHEMBL3063409 | 0.73 | MAPT (0.50) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL3063475 | 0.72 | ADORA2B (0.58) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL29699319 | 0.71 | CFTR (0.50) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL2371359 | 0.71 | CFTR (0.50) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL3063750 | 0.70 | ALDH1A1 (0.46) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL3058599 | 0.69 | ADORA2B (0.57) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL3066367 | 0.68 | KDM4E (0.46) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL3073764 | 0.68 | PLAU (0.44) | MAPTHSD17B10MEN1ALDH1A1POLB | |
| SCHEMBL3058552 | 0.67 | ALDH1A1 (0.51) | MAPTHSD17B10MEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113894-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2011-09-22 | — | — | WO | disclosed |