Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967817 | 0.72 | LTA4H (0.48) | LTA4HCYP11B1CYP11B2LMNAHTT | |
| SCHEMBL231309 | 0.72 | LTA4H (0.48) | LTA4HHTTSMN1; SMN2GRM2MEN1 | |
| SCHEMBL31229158 | 0.71 | CYP11B1 (0.62) | LTA4HCYP11B1CYP11B2LMNAHTT | |
| SCHEMBL18151986 | 0.69 | TNF (0.52) | CYP11B1CYP11B2LMNAHTTSMN1; SMN2 | |
| SCHEMBL3960228 | 0.69 | LTA4H (0.52) | LTA4HLMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13508713 | 0.69 | CYP11B1 (0.62) | LTA4HCYP11B1CYP11B2LMNAHTT | |
| SCHEMBL17185609 | 0.69 | LTA4H (0.48) | LTA4HCYP11B1CYP11B2LMNAHTT | |
| SCHEMBL14763692 | 0.68 | LTA4H (0.48) | LTA4HLMNAHTTSMN1; SMN2GRM2 | |
| SCHEMBL12413756 | 0.68 | POLB (0.46) | LTA4HLMNAHTTSMN1; SMN2MAPK1 | |
| SCHEMBL9697124 | 0.68 | GRM2 (0.54) | LTA4HCYP11B1CYP11B2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3450436-B1 | CONDENSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2022-07-27 | — | — | EP | disclosed |