Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 16/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25353347 | 1.00 | DGAT2 (0.68) | DGAT2KMT2AATMPOLBMEN1 | |
| SCHEMBL25353354 | 0.93 | DGAT2 (0.59) | DGAT2KMT2AATMPOLBMEN1 | |
| SCHEMBL29703034 | 0.91 | DGAT2 (0.65) | DGAT2KMT2A | |
| SCHEMBL25432123 | 0.91 | DGAT2 (0.65) | DGAT2KMT2A | |
| SCHEMBL25432125 | 0.88 | DGAT2 (0.57) | DGAT2KMT2AATMPOLBMEN1 | |
| SCHEMBL29511941 | 0.83 | DGAT2 (0.80) | DGAT2KMT2AATM | |
| SCHEMBL25349605 | 0.83 | DGAT2 (0.80) | DGAT2KMT2AATM | |
| SCHEMBL29703038 | 0.82 | ALDH1A1 (0.47) | DGAT2KMT2AMEN1 | |
| SCHEMBL25351200 | 0.82 | ALDH1A1 (0.47) | DGAT2KMT2AMEN1 | |
| SCHEMBL25352504 | 0.82 | DGAT2 (0.77) | DGAT2KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225739-A1 | PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076495-A1 | PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-04-14 | — | — | WO | disclosed |