Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | FOS | P01100 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521059 | 1.00 | KDM4E (0.40) | KDM4ERAB9ANPC1LMNAPDE4B | |
| SCHEMBL29705146 | 0.86 | KDM4E (0.35) | KDM4ERAB9ANPC1LMNAPDE4B | |
| SCHEMBL20521183 | 0.86 | KDM4E (0.35) | KDM4ERAB9ANPC1LMNAPDE4B | |
| SCHEMBL20521025 | 0.85 | BAZ2B (0.44) | KDM4ERAB9ANPC1LMNAGAA | |
| SCHEMBL29705174 | 0.85 | BAZ2B (0.44) | KDM4ERAB9ANPC1LMNAGAA | |
| SCHEMBL20521839 | 0.84 | LMNA (0.50) | KDM4ERAB9ANPC1LMNAKMT2A | |
| SCHEMBL3289956 | 0.84 | LMNA (0.50) | KDM4ERAB9ANPC1LMNAPDE4B | |
| SCHEMBL29705211 | 0.84 | LMNA (0.50) | KDM4ERAB9ANPC1LMNAKMT2A | |
| SCHEMBL20556271 | 0.83 | CYP1A2 (0.42) | KDM4ERAB9ANPC1LMNAGAA | |
| SCHEMBL29705130 | 0.83 | CYP1A2 (0.42) | KDM4ERAB9ANPC1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |