Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 3/20 | 0.34 |
| ▸ | JUN | P05412 | 3/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.34 |
| ▸ | RELA | Q04206 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | FOS | P01100 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521183 | 1.00 | KDM4E (0.35) | KDM4ENPC1RAB9APDE4BLMNA | |
| SCHEMBL29705123 | 0.87 | KDM4E (0.35) | KDM4ENPC1RAB9APDE4BLMNA | |
| SCHEMBL20521561 | 0.87 | KDM4E (0.35) | KDM4ENPC1RAB9APDE4BLMNA | |
| SCHEMBL23646765 | 0.87 | LMNA (0.44) | KDM4ENPC1RAB9APDE4BLMNA | |
| SCHEMBL29705131 | 0.86 | KDM4E (0.40) | KDM4ENPC1RAB9APDE4BLMNA | |
| SCHEMBL20521059 | 0.86 | KDM4E (0.40) | KDM4ENPC1RAB9APDE4BLMNA | |
| SCHEMBL20521317 | 0.84 | LMNA (0.36) | KDM4ENPC1RAB9ALMNACYP1A2 | |
| SCHEMBL29705104 | 0.84 | LMNA (0.36) | KDM4ENPC1RAB9ALMNACYP1A2 | |
| SCHEMBL20520654 | 0.83 | PDE4B (0.46) | KDM4EPDE4BGAAALDH1A1HPGD | |
| SCHEMBL29705143 | 0.83 | PDE4B (0.46) | KDM4EPDE4BGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |