Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 6/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30540792 | 0.78 | RAB9A (0.42) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL29705888 | 0.76 | MAPK8 (0.37) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL21733021 | 0.76 | PDK2 (0.47) | GRM4MAPK8MAPK9OPRL1RET | |
| SCHEMBL5562287 | 0.74 | KDM4E (0.41) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL9369196 | 0.73 | PDE10A (0.42) | MAPK8MAPK9MAPK10PDE10A | |
| SCHEMBL17857651 | 0.71 | HTR1A (0.40) | PIM1JAK2TYK2JAK3MKNK2 | |
| SCHEMBL26888903 | 0.70 | GCK (0.41) | PDE10A | |
| SCHEMBL3832735 | 0.70 | PDK2 (0.39) | GRM4OPRL1RETOPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL17837567 | 0.70 | HTR1A (0.40) | PIM1JAK2TYK2JAK3MKNK2 | |
| SCHEMBL28926587 | 0.70 | SMN1; SMN2 (0.45) | GRM4MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159745-A1 | GCN2 MODULATING COMPOUNDS AND USES THEREOF | HIBERCELL, INC. (US) | 2022-07-28 | — | — | WO | disclosed |