SCHEMBL30908476

SCHEMBL30908476

COC(=O)c1cc(=O)[nH]c2cc(C)ccc12

nearest known ligand 0.64

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 2/20 0.64
KDM4E B2RXH2 7/20 0.57
ALDH1A1 P00352 6/20 0.57
MAPT P10636 2/20 0.57
PKM P14618 1/20 0.57
KMT2A Q03164 3/20 0.52
MEN1 O00255 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
POLB P06746 1/20 0.49
HSD17B10 Q99714 3/20 0.49
HPGD P15428 1/20 0.49
TP53 P04637 1/20 0.48
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2799377 0.81 KDM4E (0.71) NR4A2KDM4EALDH1A1KMT2AMEN1
SCHEMBL6588128 0.78 NR4A2 (1.00) NR4A2KDM4EMAPTL3MBTL1HSD17B10
SCHEMBL2797608 0.78 KDM4E (0.51) NR4A2KDM4EALDH1A1MAPTKMT2A
SCHEMBL29707485 0.78 NR4A2 (0.47) NR4A2KDM4EALDH1A1MAPTL3MBTL1
SCHEMBL27030475 0.78 NR4A2 (0.47) NR4A2KDM4EALDH1A1MAPTL3MBTL1
SCHEMBL16938811 0.76 KDM4E (0.72) NR4A2KDM4EALDH1A1MAPTPKM
SCHEMBL14932885 0.76 NR4A2 (0.52) NR4A2KDM4EALDH1A1KMT2AMEN1
SCHEMBL9159365 0.75 KDM4E (0.49) NR4A2KDM4EALDH1A1MAPTKMT2A
SCHEMBL6009589 0.75 KIF11 (0.72) NR4A2KDM4EALDH1A1PKMKMT2A
SCHEMBL1196820 0.75 NR4A2 (0.65) NR4A2KDM4EALDH1A1MAPTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024074611-A1 PRMT5 INHIBITORS Ryvu Therapeutics S.A. (PL) 2024-04-11 WO disclosed