⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35226 | 0.96 | — | — | |
| SCHEMBL7024646 | 0.96 | — | — | |
| SCHEMBL5776485 | 0.96 | — | — | |
| Fluoride SCHEMBL21986315 | 0.93 | LMNA (0.57) | — | |
| SCHEMBL3821175 | 0.93 | — | — | |
| SCHEMBL7929388 | 0.87 | NPC1 (0.60) | — | |
| Hydrazine SCHEMBL17259295 | 0.87 | LMNA (0.50) | — | |
| SCHEMBL21617684 | 0.87 | LMNA (0.50) | — | |
| SCHEMBL28682658 | 0.84 | LMNA (0.47) | — | |
| Boric Acid SCHEMBL2461186 | 0.84 | ORAI1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107488190-B | Ezetimibe intermediate and preparation method thereof | 山东新时代药业有限公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-107488138-B | Ezetimibe synthesis method | 山东新时代药业有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-107488165-B | Ezetimibe intermediate compound | 山东新时代药业有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-107488173-B | Ezetimibe intermediate and synthetic method thereof | 山东新时代药业有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-112441959-A | Ezetimibe raw material medicine synthesis process | 石家庄市华新药业有限责任公司 | 2021-03-05 | — | — | CN | disclosed |
| CN-107488164-B | Ezetimibe intermediate compound | 山东新时代药业有限公司 | 2020-08-14 | — | — | CN | disclosed |
| CN-104892537-B | The synthetic method of Ezetimibe intermediate and Ezetimibe | 江西施美药业股份有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-107488190-A | A kind of Ezetimibe intermediate and preparation method thereof | 山东新时代药业有限公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-107488138-A | A kind of Ezetimibe synthetic method | 山东新时代药业有限公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-107488173-A | A kind of Ezetimibe intermediate and its synthetic method | 山东新时代药业有限公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-1527707-A | The use of substituted azetidinone compounds for the treatment of sitosterolemia | ���鹫˾ | 2004-09-08 | — | — | CN | disclosed |
| WO-2004050624-A1 | SUBSTITUTED 1H-PYRIDINE-2-ONE DERIVATIVES | C & C RESEARCH LABORATORIES (KR) | 2004-06-17 | — | — | WO | disclosed |
| EP-0673942-B1 | Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds | SHINETSU CHEMICAL CO (JP) | 2000-11-08 | — | — | EP | disclosed |
| CN-1050830-C | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents | SCHERING CORP (US) | 2000-03-29 | — | — | CN | disclosed |
| EP-0670322-B1 | A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it | SHINETSU CHEMICAL CO (JP) | 2000-01-19 | — | — | EP | disclosed |
| US-5641431-A | Silacyclohexanone compound and a method of preparing a silacyclohexane-type liquid crystal composition containing it | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1997-06-24 | — | — | US | disclosed |
| US-5582764-A | Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-12-10 | — | — | US | disclosed |
| CN-1131416-A | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents | SCHERING CORP (US) | 1996-09-18 | — | — | CN | disclosed |
| EP-0673942-A1 | Silacyclohexanone compounds as intermediates for the preparation of silacyclohexane-type liquid cristal compounds | Shin-Etsu Chemical Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0670322-A1 | A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it | Shin-Etsu Chemical Co., Ltd. (JP) | 1995-09-06 | — | — | EP | disclosed |