Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.56 |
| ▸ | BUB1 | O43683 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28734419 | 1.00 | TGFBR1 (0.59) | TGFBR1MAPK14TGFBR2BUB1CYP3A4 | |
| SCHEMBL28734420 | 0.82 | TGFBR1 (0.57) | TGFBR1MAPK14TGFBR2BUB1 | |
| SCHEMBL6684058 | 0.74 | TGFBR1 (1.00) | TGFBR1MAPK14CYP3A4 | |
| SCHEMBL13727304 | 0.74 | CCR1 (0.50) | TGFBR1MAPK14 | |
| SCHEMBL14726013 | 0.72 | TGFBR1 (0.76) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL18414358 | 0.72 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18397543 | 0.69 | TGFBR1 (0.83) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL20434739 | 0.69 | TGFBR1 (0.83) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL14731231 | 0.69 | TGFBR1 (0.70) | TGFBR1MAPK14TGFBR2CYP3A4 | |
| SCHEMBL18414916 | 0.68 | TGFBR1 (1.00) | TGFBR1MAPK14TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380845-A | Heterocyclic-fused compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-04-22 | — | — | CN | disclosed |