Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14726013 | 0.86 | TGFBR1 (0.76) | TGFBR1MAPK14ALDH1A1KDM4ERXFP1 | |
| SCHEMBL2906534 | 0.86 | TGFBR1 (0.76) | TGFBR1MAPK14LMNAPDE5APOLB | |
| SCHEMBL6682547 | 0.83 | TGFBR1 (1.00) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 | |
| SCHEMBL14731231 | 0.83 | TGFBR1 (0.70) | TGFBR1MAPK14LMNACYP1A2CYP3A4 | |
| SCHEMBL31061048 | 0.79 | TGFBR1 (1.00) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 | |
| SCHEMBL14262837 | 0.79 | KDM4E (0.94) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 | |
| SCHEMBL412953 | 0.79 | TGFBR1 (1.00) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 | |
| SCHEMBL414358 | 0.79 | CYP1A2 (1.00) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 | |
| SCHEMBL3117698 | 0.78 | LMNA (0.66) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 | |
| SCHEMBL6681711 | 0.78 | TGFBR1 (1.00) | TGFBR1MAPK14ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080248-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | Pfizer Limited (GB) | 2016-10-19 | — | — | EP | claimed |
| WO-2015087231-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | PFIZER LIMITED (GB) | 2015-06-18 | — | — | WO | claimed |
| US-20150159134-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | PFIZER LIMITED (GB) | 2015-06-11 | — | — | US | claimed |
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2021-09-30 | — | — | US | disclosed |
| US-20210254056-A1 | IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS | CAMP4 THERAPEUTICS CORPORATION | 2021-08-19 | — | — | US | disclosed |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200316089-A1 | 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2020-10-08 | — | — | US | disclosed |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2019-11-21 | — | — | US | disclosed |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| EP-3080248-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | Pfizer Limited (GB) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015087231-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | PFIZER LIMITED (GB) | 2015-06-18 | — | — | WO | disclosed |
| US-20150159134-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | PFIZER LIMITED (GB) | 2015-06-11 | — | — | US | disclosed |
| US-20150159134-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | PFIZER LIMITED (GB) | 2015-06-11 | — | — | US | disclosed |
| US-20150159134-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | PFIZER LIMITED (GB) | 2015-06-11 | — | — | US | disclosed |
| US-20140031547-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED | 2014-01-30 | — | — | US | disclosed |
| WO-2004065392-A1 | CONDENSED PYRIDINES AND PYRIMIDINES AND THEIR USE AS ALK-5 RECEPTOR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150159134-A1 | METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS | ALDH1A2, ALDH1A3, EYA3 | TGFBR1 4643/4885MAPK14 4549/4885ALDH1A1 302/4885 |
| US-20140031547-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1G3 | TGFBR1 2376/4885MAPK14 871/4885ALDH1A1 2473/4885 |
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | TGFBR1 2743/4885MAPK14 3639/4885ALDH1A1 65/4885 |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | TGFBR1 4064/4885MAPK14 3073/4885ALDH1A1 33/4885 |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1D | TGFBR1 3476/4885MAPK14 636/4885ALDH1A1 2638/4885 |
| US-20200316089-A1 | 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MCL1, MKI67 | TGFBR1 3817/4885MAPK14 2839/4885ALDH1A1 61/4885 |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | DCX, MKI67, MCL1 | TGFBR1 4064/4885MAPK14 3073/4885ALDH1A1 33/4885 |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | MKI67, PROX1, DCX | TGFBR1 3798/4885MAPK14 3674/4885ALDH1A1 30/4885 |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | TGFBR1 2743/4885MAPK14 3639/4885ALDH1A1 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.