Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Gamma-Aminobutyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.88 |
| ▸ | TSHR | P16473 | 3/20 | 0.88 |
| ▸ | THRB | P10828 | 2/20 | 0.88 |
| ▸ | BLM | P54132 | 2/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.88 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.88 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.88 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.88 |
| ▸ | GABRP | O00591 | 1/20 | 0.88 |
| ▸ | GABRD | O14764 | 1/20 | 0.88 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.88 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.88 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.88 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.88 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.88 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.88 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.88 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.88 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gamma-Aminobutyric Acid SCHEMBL3973563 | 0.94 | LMNA (1.00) | LMNATSHRTHRBBLMKMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL1330421 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL190459 | 0.94 | LMNA (1.00) | LMNATSHRTHRBBLMKMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL4878 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL25327475 | 0.91 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL16540621 | 0.91 | LMNA (0.94) | LMNATSHRTHRBBLMKMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL377445 | 0.91 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL20593982 | 0.91 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL20593981 | 0.91 | LMNA (0.94) | LMNATSHRTHRBBLMKMT2A | |
| Gamma-Aminobutyric Acid SCHEMBL2768665 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4829078-A | CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-05-09 | — | — | US | claimed |
| CN-113831265-B | Hydroxyl compound terminal modification functional group and method for modifying hydroxyl compound | 中国科学技术大学 | 2024-02-02 | — | — | CN | disclosed |
| CN-116135229-A | Application of hypocrellin-containing derivative with both peri-position and 2-position being simultaneously substituted in preparation of photodynamic anti-tumor drugs | 中国科学院理化技术研究所 | 2023-05-19 | — | — | CN | disclosed |
| CN-103210047-B | The diazene * dioxide of the substitution containing N and/or the aqueous polishing composition of N '-hydroxyls-diazene * oxide salts | 巴斯夫欧洲公司 | 2018-07-17 | — | — | CN | disclosed |
| EP-2614123-B1 | AQUEOUS POLISHING COMPOSITION AND PROCESS FOR CHEMICALLY MECHANICALLY POLISHING SUBSTRATE MATERIALS FOR ELECTRICAL, MECHANICAL AND OPTICAL DEVICES | BASF SE (DE) | 2017-06-28 | — | — | EP | disclosed |
| WO-2017065602-A1 | TREATING NEUROMUSCULAR OR NEUROLOGIC DISEASE THROUGH REDUCING GABAERGIC AND/OR GLYCINERGIC INHIBITORY NEUROTRANSMITTER OVERSTIMULATION | RY PHARMA B.V. (NL) | 2017-04-20 | — | — | WO | disclosed |
| WO-2016114655-A1 | TREATING NEUROMUSCULAR OR NEUROLOGIC DISEASE THROUGH REDUCING GABAERGIC AND/OR GLYCINERGIC INHIBITORY NEUROTRANSMITTER OVERSTIMULATION | RY PHARMA B.V. (NL) | 2016-07-21 | — | — | WO | disclosed |
| CN-103189457-B | For moisture polishing composition and the method for chemically machinery polished electronics, machinery and optics base material | BASF SE (DE) | 2015-12-09 | — | — | CN | disclosed |
| CN-103690627-B | Electuary having health function of assisting to improve memory | CHENG GANG | 2015-07-08 | — | — | CN | disclosed |
| CN-103080256-B | Aqueous polishing composition and process for chemically mechanically polishing substrates containing silicon oxide dielectric and polysilicon films | BASF SE | 2015-06-24 | — | — | CN | disclosed |
| WO-2012032469-A1 | AQUEOUS POLISHING COMPOSITION AND PROCESS FOR CHEMICALLY MECHANICALLY POLISHING SUBSTRATE MATERIALS FOR ELECTRICAL, MECHANICAL AND OPTICAL DEVICES | BASF SE (DE) | 2012-03-15 | — | — | WO | disclosed |
| WO-2012032467-A1 | PROCESS FOR CHEMICALLY MECHANICALLY POLISHING SUBSTRATES CONTAINING SILICON OXIDE DIELECTRIC FILMS AND POLYSILICON AND/OR SILICON NITRIDE FILMS | BASF SE (DE) | 2012-03-15 | — | — | WO | disclosed |
| EP-2428541-A1 | Aqueous polishing composition and process for chemically mechanically polishing substrates containing silicon oxide dielectric and polysilicon films | BASF SE (DE) | 2012-03-14 | — | — | EP | disclosed |
| CN-102319394-A | Xingnaojing composition for injection and preparation method thereof | LIANHUA ZHAO | 2012-01-18 | — | — | CN | disclosed |
| US-20070092942-A1 | Ubiquitin specific enzymes of family herpesviridae | KORBEL GREGORY | 2007-04-26 | — | — | US | disclosed |
| WO-2007022455-A2 | UBIQUITIN SPECIFIC ENZYMES OF FAMILY HERPESVIRIDAE | PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) | 2007-02-22 | — | — | WO | disclosed |
| CN-1634501-A | Xingnaojing injection and preparation method thereof | ZHANG WENFANG (CN) | 2005-07-06 | — | — | CN | disclosed |
| EP-0614487-A4 | DNA ENCODING A GLYCINE TRANSPORTER AND USES THEREOF. | SYNAPTIC PHARMA CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0614487-A1 | DNA ENCODING A GLYCINE TRANSPORTER AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1994-09-14 | — | — | EP | disclosed |
| WO-1993010228-A1 | DNA ENCODING A GLYCINE TRANSPORTER AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1993-05-27 | — | — | WO | disclosed |