Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 7/20 | 0.38 |
| ▸ | TYK2 | P29597 | 7/20 | 0.38 |
| ▸ | JAK3 | P52333 | 7/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29498945 | 0.90 | JAK2 (0.35) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24539588 | 0.90 | JAK2 (0.44) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24539861 | 0.85 | ALDH1A1 (0.39) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL29732784 | 0.78 | FGFR3 (0.44) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL24539590 | 0.78 | JAK2 (0.42) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL24539461 | 0.78 | JAK2 (0.42) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL24539477 | 0.77 | JAK2 (0.46) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL29733004 | 0.76 | MAPT (0.42) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL24327357 | 0.76 | JAK2 (0.39) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24539406 | 0.75 | JAK2 (0.45) | JAK2JAK1TYK2JAK3F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698005-B | Fused ring AhR inhibitors | 山东轩竹医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022127753-A1 | FUSED RING AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-06-23 | — | — | WO | disclosed |